Marijuana Use In The Elderly Implications And Considerations
The frequency of 32.9 % of medical-only cannabis use was higher in this cohort than the 17 % reported in the National Survey on Drug Use and Health. A new study from researchers affiliated with two midwestern universities has found that the medicinal use of cannabis improves the quality of life of seniors. To conduct the study, a team of researchers affiliated with the University of Illinois and the University of Iowa surveyed 139 seniors about their use of medical cannabis and self – reported changes in outcome over a period of one year. However, pain is not the only indication for medical cannabis use; studies have shown that cannabis use improved sleep, reduced spasticity, and enhanced health-related quality of life benefits which were observed in the current analysis. Marijuana Use In The Elderly Implications And Considerations.
As more patients have begun asking about marijuana use, Fixen has had to educate herself on drug interactions and how marijuana might affect older patients. Because so many older adults have come to the Seniors Clinic asking about marijuana, Fixen and Orosz teamed up to do a study on marijuana use among patients. His paper pointed out that more older adults are using cannabis, and many of them are using it for medicinal reasons, and in place of prescription medications. Since Colorado legalized marijuana for both recreational and medical use, stigma has decreased, and that could be one reason that reports of marijuana use are on the rise. There is substantial growth in the use of medical cannabis in recent years and with the aging of the population, medical cannabis is increasingly used by the elderly.
Effects of marijiana used
In summary, the present novel cluster analysis among current cannabis – using athletes found three distinct cannabis user – type clusters that were associated with positive and adverse subjective effects to cannabis. The present analysis used cluster analysis to successfully create cannabis use phenotypes which were used to help determine who responds to positive and adverse cannabis subjective effects. These analyses revealed ( 1 ) three distinct cannabis user – type clusters, ( 2 ) differences in subjective effects to cannabis by these cannabis user – type clusters, and ( 3 ) combined THC and CBD use provided the largest benefits in well – being and calm. This cross-sectional survey in 1161 athletes with 301 current cannabis users applied data reduction techniques to examine whether cannabis user – type clusters exist and whether these clusters are associated with subjective effects to cannabis. Marijuana Use In The Elderly Implications And Considerations
Effects of marijuana use
#reported #effect #balance #problems #patients
The most common side effects were sleepiness ( 13 % ), balance problems ( 7 % ), and gastrointestinal disturbances ( 7 % ). At first, about a third of patients experienced adverse effects — mostly sleepiness, balance problems, and gastrointestinal disturbances — but in 13 % of patients, those problems resolved when dosages were adjusted. Fibromyalgia patients who used cannabis reported strong relief from sleep disorders, improvement in pain and stiffness, they were more relaxed and reported a higher degree of well – being; at least one adverse side effect was reported by almost all of the participants. About 16 percent also reported that they had experienced a side effect from marijuana, including loss of balance, dizziness, a “strange feeling,” blurred vision, dry mouth, or anxiety.
Marijuana use in pregnancy and lactation a review of the evidence
#health #professionals #smoking #care
The question that guided the review was: what are the evidence linking cannabis smoking, oral disease, and oral health care? Further research is needed to fully understand the consequences of cannabis smoking on oral disease and the implications for oral health care. Cannabis and dental public health D’Amore et al.15 To examine the effects of alcohol, stimulants, opioids, and cannabis on oral health cannabis Shift from Illicit to Luxury. Despite the limitations, this review is a succinct synthesis of available evidence on cannabis smoking and oral health and has the potential to inform dental professionals. Momen – Heravi and Kang31 enjoined dentists to watch for general and oral – health-related cannabis manifestations when providing clinical care. Awareness of the various forms of cannabis, modes of consumption, and possible oral health effects will inform optimal dental care for cannabis smokers.1 Systematically asking the client’s history of cannabis use can help dental professionals avoid possible interactions between cannabis and drugs used in the dental clinic.
#pain #age #sleep #decrease
Although ADLs decrease as one age, chronic pain can severely limit the ADL24 and increase fear of movement, which further decreases ADLs, inadvertently increasing pain. n the elderly, sleep disturbance also can be attributed to medications, such as long – term use of pain medications, because they can lessen sleep quality by disrupting REM cycles and decreasing the length of sleep. It appears that certain pain conditions increase with age ( ie, degenerative joint disease ), whereas others decline with age ( those that have a work-related mechanical component ). In addition to the physical aging process discussed above, old age is marked by an array of psychosocial conditions that can influence the pain experience of the elderly. We distinguished among the categories of chronic cancer pain and non – cancer pain management, Parkinson’s disease, sleep disorders, anorexia, post-traumatic stress disorder, spasticity, and palliative treatment.
Marijuana use in Canada
#medications #providing #information #protein #number
Although prescribing information ( PI ) is often the initial source of information, it may only provide a limited number of exemplars or only reference a class of medications without providing any specific medication examples. Although prescribing information ( PI ) is often the initial source of information when identifying potential drug-drug interactions, it may only provide a limited number of exemplars or only reference a class of medications without providing any specific medication examples. The FDA approved PI for the nabilone ( Cesamet(r ) ) states “highly bound” but without providing a specific percentage, nor does the DrugBank drug monograph provide a specific percentage of protein binding The percentage used to identify highly protein-bound medications was interpreted from a report by Scheife that states “differences appear to be of slight clinical importance” when protein binding is “less than 80 – 85 %”
Marijuana use in the united states
#study #groups #data #results #abstracts
These results are similar to the results of a previous study performed by our group, and to other studies performed in the United States. The researchers then jointly reviewed the abstracts in the included and undecided groups and agreed on abstracts to undergo full-text screening. The study design is also not appropriate for combining and re-analyzing quantitative results and adjusting for the variable sample sizes of individual studies. Marijuana Use In The Elderly Implications And Considerations relevant data were extracted from the 23 articles and transferred to a spreadsheet; this information included the purpose and objectives of the study, the design, study population, sample size, outcomes, or results, key messages, and conclusion. Gathering more evidence-based data, including data from double-blind randomized – controlled trials, in this special population is imperative.
#CBD #FDA #interactions
Important education points including drug-drug interactions, drug-disease interactions, and signs and symptoms of acute overdose should be considered. As per the FDA website, these tables provide drug-drug interaction examples and were not intended to be a complete list. Tables within the FDA “Drug Development and Drug Interactions: Table of Substrates, Inhibitors, and Inducers” online document was recently revised on December 3rd, 2019. Drug Interactions: Information from studies of the FDA – approved CBD drug Epidiolex shows that there is a risk of CBD impacting other medicines you take – or that other medicines you take could impact the dose of CBD that can safely be used. The concern for potential drug-drug interactions is of increasing concern and the subject of several recent reviews
Cannabis use among older adults rising rapidly
#CBD #THC #cannabinoids #cannabidiol #extracts
Most cannabis chemovars ( “strains” ) are divided between THC – predominant, containing between 10 % to 20 % THC and less than 5 % of CBD, and CBD – predominant, containing 10 % to 24 % CBD and less than 5 % of THC. CBD – predominant chemovars are added to THC therapy since CBD can balance the psychoactive adverse effect of THC, especially during the daytime. Current cannabis research and manufacturing enable us to discuss cannabis medications only at the level of these cannabinoids, THC, and CBD. Participants took various ratios of tetrahydrocannabinol ( THC ) to cannabidiol ( CBD ) by mouth as a liquid extract tincture, capsule, or in an electronic vaporizer, for an average of 16.8 weeks.
#substance #disorders #people #incarceration
Other risks for people with substance use disorders include decreased access to health care, housing insecurity, and a greater likelihood of incarceration. Additionally, individuals with a substance use disorder are more likely to experience homelessness or incarceration than those in the general population, and these circumstances pose unique challenges regarding the transmission of the virus that causes COVID-19. We must also ensure that patients with substance use disorders are not discriminated against if a rise in COVID-19 cases places an added burden on our healthcare system. As people across the U.S. and the rest of the world contend with coronavirus disease 2019 ( COVID-19 ), the research community should be alert to the possibility that it could hit some populations with substance use disorders ( SUDs ) particularly hard.
The Effects of Marijuana on Your Body
#disease #lung #COPD #SARS
It is, therefore, Marijuana Use In The Elderly Implications And Considerations reasonable to be concerned that compromised lung function or lung disease related to smoking history, such as chronic obstructive pulmonary disease ( COPD ), could put people at risk for serious complications of COVID-19. Co-occurring conditions including COPD, cardiovascular disease, and other respiratory diseases have been found to worsen prognosis in patients with other coronaviruses that affect the respiratory system, such as those that cause SARS and MERS. Chronic respiratory disease is already known to increase overdose mortality risk among people taking opioids, and thus diminished lung capacity from COVID-19 could similarly endanger this population. These findings provide further evidence against the notion that marijuana is a risk factor for the development of emphysema, although the low – attenuation findings at the apices could be clinically relevant regarding potential risks for barotrauma and bullous lung disease
#smokers #smoking #marijuana #compared
Compared with non – cannabis smokers, people who smoked cannabis had a 6 – 19 % greater chance of developing periodontitis ( PR 1.12, 95 % CI 1.06 – 1.19 ). However, the difference in caries prevalence was not significant in a sub-analysis that compared cannabis smokers to non – smokers. Smoking marijuana should be deferred due to the deleterious effects of chronic cannabis smoking on lung function and respiratory symptoms . However, cessation of marijuana smoking by marijuana – only smokers has been associated with the resolution of preexisting symptoms of chronic bronchitis. In another study, Darling and colleagues20 reported significantly higher amounts of Candida albicans in the mouths of cannabis smokers compared with non – smokers.
#increasing #blood #concentrations #kidney
Limited kidney and liver function increase the half-life and alter the excretion process of medications,12 increasing the risk for a possible drug overdose. And cannabis can cause side effects when mixed with other medications, such as increasing the risk of bleeding, lowering blood pressure, and affecting blood sugar levels. Inhaling cannabis delivers a high dose in a very short period, but soon thereafter, there is a relatively rapid decline, and abrupt changes in blood concentration of cannabinoids can increase the risk of adverse events. This variability among subjects makes it difficult to achieve stable concentrations, and thus puts older adults at high risk for adverse events. Blood concentrations are lower in about 5- to 25-fold as compared to intravenous administration due to the first-pass metabolism in the intestines and liver.
Marijuana Use In The Elderly Implications And Considerations
#liver #increased #dose
Although this risk was increased when taken with other drugs that impact the liver, signs of liver injury were seen also in patients, not on those drugs Since this may increase the risk of adverse events, a reduction in dose of the CYP2C19 SUBSTRATE medication should be considered. The authors further stated that “CBD also widens THC’s therapeutic window when administered concomitantly, increasing the maximum tolerated dose and decreasing the risk for adverse events”.The occurrence of this liver injury was identified through blood tests, as is often the case with early problems with the liver. The coadministration of nabiximols with other CYP3A4 SUBSTRATES with an NTI may result in an increase in the effect of the concomitant drug. Marijuana Use In The Elderly Implications And Considerations.
Are marijuana and seniors a bad combination?
#enzyme #metabolism #UGT #medications #reactions
Combined, this cytochrome P450 and UGT enzymes metabolize more than 90 % of medications that are dependent on hepatic metabolism. Most xenobiotic medications are metabolized by a phase I hepatic cytochrome P450 enzyme ( oxidative / functionalization reaction ) and then by a phase II conjugation reaction catalyzed by a hepatic UDP – glucuronosyltransferase ( UGT ) enzyme [ 19, ].  CBD can also INHIBIT the metabolism of OTHER medications by the UGT1A9 enzyme ( e.g., diflunisal, propofol, and fenofibrate ) and UGT2B7 enzyme ( e.g., gemfibrozil, lamotrigine, morphine, and lorazepam ). Marijuana Use In The Elderly Implications And Considerations, In this case, CBD is metabolized by UGT1A9 and UGT2B7 enzymes in the liver and UGT1A7 that are expressed in the gastrointestinal tract